NanoInterventions

NanoInterventions' Mouse Stent Model for Screening Novel Cardiovascular Therapies

First disease model to test stent efficacy

Models human vascular response to stent injury

Miniature stent combined with powerful new coating process

Harnesses full potential of mouse genome database

Genetically modified strains and disease models: e.g. ApoE knockout for atherosclerosis

Probe genes and pathways

Donor-recipient crosses, i.e. lacZ, enable tracking source of endothelial and other cell types involved in the stent injury response

New Tools to Speed Your Cardiovascular Product Development

Custom coating service
- Stents and other intravascular implants
- ElectroNanospray™ process
- Optimization for specific release profiles

Stent design and procurement

Proprietary drug-eluting polymer system

Drug elution profiles with full analytical services

Preclinical studies (GLP) in multiple species
- High throughput screening-mouse stent model
- Standard models-rat, rabbit, pig

Biocompatibility testing

Histopathology, histology scoring, serology

Consulting - Preclinical study design and protocol development
- Support and guidance

Reports for FDA submissions

Supporting documents for NIH grant submissions

NIH/NSF SBIR/STTR collaborations